Journal article
The infant gut resistome associates with E. coli, environmental exposures, gut microbiome maturity, and asthma-associated bacterial composition
University of Copenhagen1
University of California at San Diego2
Department of Health Technology, Technical University of Denmark3
Bioinformatics, Department of Health Technology, Technical University of Denmark4
Bayesian Modeling & Molecular Evolution, Bioinformatics, Department of Health Technology, Technical University of Denmark5
Metagenomics, Bioinformatics, Department of Health Technology, Technical University of Denmark6
Antimicrobial resistance (AMR) is an accelerating global threat, yet the nature of AMR in the gut microbiome and how AMR is acquired during early life remain largely unknown. In a cohort of 662 Danish children, we characterized the antibiotic resistance genes (ARGs) acquired during the first year of life and assessed the impacts of diverse environmental exposures on ARG load.
Our study reveals a clear bimodal distribution of ARG richness that is driven by the composition of the gut microbiome, especially E. coli. ARG profiles were significantly affected by various environmental factors. Among these factors, the importance of antibiotics diminished with time since treatment.
Finally, ARG load and ARG clusters were also associated with the maturity of the gut microbiome and a bacterial composition associated with increased risk of asthma. These findings broaden our understanding of AMR in early life and have critical implications for efforts to mitigate its spread.
| Language: | English |
|---|---|
| Year: | 2021 |
| Pages: | 975-987 |
| ISSN: | 19346069 and 19313128 |
| Types: | Journal article |
| DOI: | 10.1016/j.chom.2021.03.017 |
| ORCIDs: | 0000-0003-1541-6212 , 0000-0001-8839-7003 , 0000-0003-4131-7592 , 0000-0001-6227-9906 and Vestergaard, Gisle Alberg |
Anti-Bacterial Agents Asthma Child Child, Preschool Cohort Studies DNA, Bacterial Drug Resistance, Microbial E. coli Environmental Exposure Escherichia coli Feces Female Gastrointestinal Microbiome Genes, Bacterial Humans Infant Infant, Newborn Male Metagenomics Pregnancy Proteobacteria Risk Assessment antibiotic resistance genes antibiotics asthma-associated bacterial composition environmental exposure gut bacterial maturity gut microbiome gut resistome health risk infant
