Journal article
Miniature ultrasound ring array transducers for transcranial ultrasound neuromodulation of freely-moving small animals
Korea Advanced Institute of Science and Technology1
Department of Electrical Engineering, Technical University of Denmark2
Magnetic Resonance, Department of Health Technology, Technical University of Denmark3
Center for Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark4
Background: Current transcranial ultrasound stimulation for small animal in vivo experiment is limited to acute stimulation under anesthesia in stereotaxic fixation due to bulky and heavy curved transducers. Methods: We developed a miniaturized ultrasound ring array transducer which is capable of invoking motor responses through neuromodulation of freely-moving awake mice.
Results:: The developed transducer is a 32-element, 183-kHz ring array with a weight of 0.035 g (with PCB: 0.73 g), a diameter of 8.1 mm, a focal length of 2.3 mm, and lateral resolution of 2.75 mm. By developing an affixation scheme suitable for freely-moving animals, the transducer was successfully coupled to the mouse brain and induced motor responses in both affixed and awake states.
Conclusion: Ultrasound neuromodulation of a freely-moving animal is now possible using the developed lightweight and compact system to conduct a versatile set of in vivo experiments.
Language: | English |
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Publisher: | Elsevier |
Year: | 2018 |
Pages: | 251-255 |
ISSN: | 18764754 and 1935861x |
Types: | Journal article |
DOI: | 10.1016/j.brs.2018.11.007 |
ORCIDs: | 0000-0001-9963-2515 , Pasquinelli, Cristina and Thielscher, Axel |