Journal article
Whole organ and tissue reconstruction in thoracic regenerative surgery
Advanced Center for Translational Regenerative Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.1
Development of novel prognostic, diagnostic, and treatment options will provide major benefits for millions of patients with acute or chronic respiratory dysfunction, cardiac-related disorders, esophageal problems, or other diseases in the thorax. Allogeneic organ transplant is currently available. However, it remains a trap because of its dependency on a very limited supply of donated organs, which may be needed for both initial and subsequent transplants.
Furthermore, it requires lifelong treatment with immunosuppressants, which are associated with adverse effects. Despite early clinical applications of bioengineered organs and tissues, routine implementation is still far off. For this review, we searched the PubMed, MEDLINE, and Ovid databases for the following keywords for each tissue or organ: tissue engineering, biological and synthetic scaffold/graft, acellular and decelluar(ized), reseeding, bioreactor, tissue replacement, and transplantation.
We identified the current state-of-the-art practices in tissue engineering with a focus on advances during the past 5 years. We discuss advantages and disadvantages of biological and synthetic solutions and introduce novel strategies and technologies for the field. The ethical challenges of innovation in this area are also reviewed.
Language: | English |
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Year: | 2013 |
Pages: | 1151-1166 |
ISSN: | 19425546 and 00256196 |
Types: | Journal article |
DOI: | 10.1016/j.mayocp.2013.03.011 |
3-dimensional 3D 3D - 3-dimensional Bioreactors Cardiac Surgical Procedures Digestive System Surgical Procedures ECM ECM - extracellular matrix Humans IL IL - interleukin Immune System Phenomena Larynx Lung MHC MHC - major histocompatibility complex MSC MSC - mesenchymal stem cell NCD NCD - noncommunicable disease Organ Transplantation Regenerative Medicine SIS SIS - small intestine submucosa Stem Cell Transplantation TE TE - tissue engineering Thoracic Surgical Procedures Tissue Engineering Tissue Scaffolds Trachea extracellular matrix interleukin major histocompatibility complex mesenchymal stem cell noncommunicable disease small intestine submucosa tissue engineering