Journal article
Drug Delivery by an Enzyme-Mediated Cyclization of a Lipid Prodrug with Unique Bilayer-Formation Properties
Department of Chemistry, Technical University of Denmark1
Physical Chemistry, Department of Chemistry, Technical University of Denmark2
Sustainable and Green Chemistry, Department of Chemistry, Technical University of Denmark3
Colloids and Biological Interfaces Group, Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark4
Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark5
Department of Micro- and Nanotechnology, Technical University of Denmark6
Special delivery: Liposomal drug-delivery systems in which prodrugs are activated specifically by disease-associated enzymes have great potential for the treatment of severe diseases, such as cancer. A new type of phospholipid-based prodrug has the ability to form stable small unilamellar vesicles (see picture).
Activation of the prodrug vesicles by the enzyme sPLA2 initiates a cyclization reaction, which leads to the release of the drug.
| Language: | English |
|---|---|
| Publisher: | WILEY-VCH Verlag |
| Year: | 2009 |
| Pages: | 1823-1826 |
| ISSN: | 15213773 , 14337851 and 05700833 |
| Types: | Journal article |
| DOI: | 10.1002/anie.200805241 |
| ORCIDs: | Peters, Günther H.j. , Madsen, Robert and Andresen, Thomas Lars |
