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Report

Effects of azole fungicides on the function of sex and thyroid hormones

By Kjærstad, Mia Birkhøj1,2; Andersen, Helle Raun3; Taxvig, Camilla1,2; Hass, Ulla1,2; Petersen, Marta Axelstad1,2; Metzdorff, Stine Broeng1,2; Vinggaard, Anne2

From

Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark1

National Food Institute, Technical University of Denmark2

University of Southern Denmark3

Azole-fungicides are frequently used in Denmark. Epoxiconazole, propiconazole, and tebuconazole had endocrine disrupting properties in cell based assays. In rats, epoxiconazole and tebuconazole increased gestational length, maternal progesterone level, and masculinized female-offspring. Besides, tebuconazole caused feminization of male-offspring.

Similar effects were previously demonstrated for prochloraz. The results indicate that azole-fungicides in general have endocrine disrupting properties.

Language: English
Publisher: Miljøstyrelsen
Year: 2007
Series: Pesticides Research - Report for the Danish Epa
Types: Report
ORCIDs: Taxvig, Camilla , Hass, Ulla , Petersen, Marta Axelstad and Vinggaard, Anne

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