Journal article
Brain tumor vessels—a barrier for drug delivery
Colloids & Biological Interfaces, Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark1
Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark2
Department of Health Technology, Technical University of Denmark3
Danish Cancer Society4
Cancer treatment remains a challenge due to a high level of intra- and intertumoral heterogeneity and the rapid development of chemoresistance. In the brain, this is further hampered by the blood-brain barrier that reduces passive diffusion of drugs to a minimum. Tumors grow invasively and form new blood vessels, also in brain tissue where remodeling of pre-existing vasculature is substantial.
The cancer-associated vessels in the brain are considered leaky and thus could facilitate the transport of chemotherapeutic agents. Yet, brain tumors are extremely difficult to treat, and, in this review, we will address how different aspects of the vasculature in brain tumors contribute to this.
Language: | English |
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Publisher: | Springer US |
Year: | 2020 |
Pages: | 959-968 |
ISSN: | 15737233 and 01677659 |
Types: | Journal article |
DOI: | 10.1007/s10555-020-09877-8 |
ORCIDs: | Hempel, Casper , 0000-0002-5856-0161 , Andresen, Thomas L. and Kostrikov, Serhii |
Blood vessels Blood-brain barrier Brain tumors Drug delivery Glioblastoma SDG 3 - Good Health and Well-being
Animals Antineoplastic Agents Blood-Brain Barrier Brain Neoplasms Humans