Journal article
Emergence of carp edema virus (CEV) and its significance to European common carp and koi Cyprinus carpio
Cefas Weymouth Laboratory1
National Veterinary Research Institute2
National Veterinary Institute, Technical University of Denmark3
Fish Diseases, Division for Diagnostics & Scientific Advice, National Veterinary Institute, Technical University of Denmark4
Instituto Zooprofilattico Sperimentale delle Venezie5
University of South Bohemia6
Czech Academy of Agricultural Sciences7
University of Florida8
Wageningen University & Research9
University of Veterinary Medicine Hannover, Foundation10
Friedrich-Loeffler-Institute11
Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail12
University of Bern13
University of Veterinary Medicine Vienna14
Norwegian Veterinary Institute15
Vetofish16
...and 6 moreCarp edema virus disease (CEVD), also known as koi sleepy disease, is caused by a poxvirus associated with outbreaks of clinical disease in koi and common carp Cyprinus carpio. Originally characterised in Japan in the 1970s, international trade in koi has led to the spread of CEV, although the first recognised outbreak of the disease outside of Japan was not reported until 1996 in the USA.
In Europe, the disease was first recognised in 2009 and, as detection and diagnosis have improved, more EU member states have reported CEV associated with disease outbreaks. Although the structure of the CEV genome is not yet elucidated, molecular epidemiology studies have suggested distinct geographical populations of CEV infecting both koi and common carp.
Detection and identification of cases of CEVD in common carp were unreliable using the original PCR primers. New primers for conventional and quantitative PCR (qPCR) have been designed that improve detection, and their sequences are provided in this paper. The qPCR primers have successfully detected CEV DNA in archive material from investigations of unexplained carp mortalities conducted > 15 yr ago.
Improvement in disease management and control is possible, and the principles of biosecurity, good health management and disease surveillance, applied to koi herpesvirus disease, can be equally applied to CEVD. However, further research studies are needed to fill the knowledge gaps in the disease pathogenesis and epidemiology that, currently, prevent an accurate assessment of the likely impact of CEVD on European koi and common carp aquaculture and on wild carp stocks.
Language: | English |
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Year: | 2017 |
Pages: | 155-166 |
ISSN: | 16161580 and 01775103 |
Types: | Journal article |
DOI: | 10.3354/dao03164 |
ORCIDs: | Olesen, Niels Jørgen and Vendramin, Niccolò |
Animals Carps Europe Fish Diseases Poxviridae Poxviridae Infections