Conference paper
Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
Department of Health Technology, Technical University of Denmark1
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark2
National Food Institute, Technical University of Denmark3
Dublin City University4
Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract.
The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.
| Language: | English |
|---|---|
| Year: | 2019 |
| Proceedings: | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Types: | Conference paper |
| ORCIDs: | Thoppe Rajendran, Sriram , Hwu, En-Te , Nielsen, Line Hagner , Zór, Kinga and Boisen, Anja |
