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Journal article

PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

By Koefoed Petersen, Rasmus1; Benzon Larsen, Signe1; Jensen, Ditte Marie2; Christensen, Jane3; Olsen, Anja3; Loft, Steffen1; Nellemann, Christine Lydia4,5; Overvad, Kim6; Kristiansen, Karsten1; Tjønneland, Anne3; Vogel, Ulla Birgitte5 ...and 1 more

From

University of Copenhagen1

Roskilde University2

Danish Cancer Society3

Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark4

National Food Institute, Technical University of Denmark5

Aarhus University6

Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro12Ala in alcohol related breast cancer.

In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.

Language: English
Year: 2012
Pages: 59-68
ISSN: 18727980 and 03043835
Types: Journal article
DOI: 10.1016/j.canlet.2011.10.009
ORCIDs: Nellemann, Christine Lydia , 0000-0001-9522-7678 , 0000-0001-9552-8518 , 0000-0002-6024-0917 and 0000-0001-6429-7921
Keywords

SDG 3 - Good Health and Well-being

Other keywords

Aged Alcohol Drinking Breast Neoplasms Denmark Ethanol Female Heat-Shock Proteins Humans Middle Aged PPAR gamma PPARGC1A protein, human Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Transcription Factors

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