Journal article
25th anniversary of the Berlin Workshop on Developmental Toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth
Federal Institute for Risk Assessment1
National Food Institute, Technical University of Denmark2
Research Group for Chemical Risk Assessment and GMO, National Food Institute, Technical University of Denmark3
Fraunhofer Institute for Toxicology and Experimental Medicine4
National Institute of Health Sciences Tokyo5
Konstanz University of Applied Sciences6
Istituto Superiore di Sanita7
University of Copenhagen8
National School of Public Health – Oswaldo Cruz Foundation9
United States Environmental Protection Agency10
OECD11
The Institute of Environmental Toxicology12
BASF Schweiz AG13
Berlin14
Kyoto University15
Max Planck Institute for Molecular Biomedicine16
European Commission Joint Research Centre Institute17
Robert Koch Institute18
Fudan University19
Tokyo Keizai University20
Technische Universität Dresden21
Chiba Institute of Science22
...and 12 more25 years after the first Berlin Workshop on Developmental Toxicity this 10th Berlin Workshop aimed to bring together international experts from authorities, academia and industry to consider scientific, methodologic and regulatory aspects in risk assessment of developmental toxicity and to debate alternative strategies in testing developmental effects in the future.
Proposals for improvement of the categorization of developmental effects were discussed as well as the update of the DevTox database as valuable tool for harmonization. The development of adverse outcome pathways relevant to developmental neurotoxicity (DNT) was debated as a fundamental improvement to guide the screening and testing for DNT using alternatives to animal methods.
A further focus was the implementation of an in vitro mechanism-based battery, which can support various regulatory applications associated with the assessment of chemicals and mixtures. More interdisciplinary and translation research should be initiated to accelerate the development of new technologies to test developmental toxicity.
Technologies in the pipeline are (i) high throughput imaging techniques, (ii) models for DNT screening tests, (iii) use of computer tomography for assessment of thoracolumbar supernumerary ribs in animal models, and (iv) 3D biofabrication of bone development and regeneration tissue models. In addition, increased collaboration with the medical community was suggested to improve the relevance of test results to humans and identify more clinically relevant endpoints.
Finally, the participants agreed that this conference facilitated better understanding innovative approaches that can be useful for the identification of developmental health risks due to exposure to chemical substances.
Language: | English |
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Year: | 2021 |
Pages: | 155-162 |
ISSN: | 18731708 and 08906238 |
Types: | Journal article |
DOI: | 10.1016/j.reprotox.2020.11.003 |
ORCIDs: | Bennekou, Susanne Hougaard |