Conference paper
Nanoimprinted distributed feedback dye laser sensor for real-time imaging of small molecule diffusion
Label-free imaging is a promising tool for the study of biological processes such as cell adhesion and small molecule signaling processes. In order to image in two dimensions of space current solutions require motorized stages which results in low imaging frame rates. Here, a highly sensitive distributed feedback (DFB) dye laser sensor for real-time label-free imaging without any moving parts enabling a frame rate of 12 Hz is presented.
The presence of molecules on the laser surface results in a wavelength shift which is used as sensor signal. The unique DFB laser structure comprises several areas of different grating periods which result in distinct laser emission wavelengths. Imaging in two dimensions of space is enabled by focusing an image of the laser surface with a cylindrical lens onto the entrance slit of an imaging spectrometer.
Imaging is demonstrated by monitoring of diffusing small sucrose molecules in water.
Language: | English |
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Publisher: | IEEE |
Year: | 2014 |
Pages: | 1384-1386 |
Proceedings: | IEEE Sensors 2014 |
ISBN: | 1479901601 , 1479901628 , 9781479901609 and 9781479901623 |
Types: | Conference paper |
DOI: | 10.1109/ICSENS.2014.6985270 |
ORCIDs: | Vannahme, Christoph , Dufva, Martin and Kristensen, Anders |