Journal article
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
University of Paris1
Visual Computing, Department of Applied Mathematics and Computer Science, Technical University of Denmark2
Department of Applied Mathematics and Computer Science, Technical University of Denmark3
Sorbonne Université4
University of Patras5
Institute of Science and Technology Austria6
Adult neural stem cells and multiciliated ependymal cells are glial cells essential for neurological functions. Together, they make up the adult neurogenic niche. Using both high-throughput clonal analysis and single-cell resolution of progenitor division patterns and fate, we show that these two components of the neurogenic niche are lineally related: adult neural stem cells are sister cells to ependymal cells, whereas most ependymal cells arise from the terminal symmetric divisions of the lineage.
Unexpectedly, we found that the antagonist regulators of DNA replication, GemC1 and Geminin, can tune the proportion of neural stem cells and ependymal cells. Our findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult neural stem cells.
Language: | English |
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Publisher: | Cell Press |
Year: | 2019 |
Pages: | 159-172 |
ISSN: | 10974199 and 08966273 |
Types: | Journal article |
DOI: | 10.1016/j.neuron.2019.01.051 |
ORCIDs: | Shihavuddin, ASM |
Cell division Cell lineage GemC1 Geminin family Multiciliated ependymal cells Multiciliogenesis Neural stem cells Radial glial cells Symmetric division
Adult Stem Cells Animals Astrocytes Carrier Proteins Cell Cycle Proteins Cell Lineage DNA Replication Electroporation Embryo, Mammalian Ependyma Ependymoglial Cells Geminin Gmnc protein, mouse Gmnn protein, mouse Mice Neural Stem Cells cell division cell lineage geminin family multiciliated ependymal cells multiciliogenesis neural stem cells radial glial cells symmetric division