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title:(Ion AND Channels)

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10 items by relevance
1 Book chapter

Ion Channels

Lundbæk, Jens August

Wiley Encyclopedia of Chemical Biology — 2008

Year: 2008

Language: English

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2 Journal article

Lipid Bilayer – mediated Regulation of Ion Channel Function by Amphiphilic Drugs

Lundbæk, Jens August

Journal of General Physiology — 2008, Volume 131, Issue 5, pp. 421-429

Drugs that at pico- to nanomolar concentration regulate ion channel function by high-affi nity binding to their cognate receptor often have a “ secondary pharmacology, ” in which the same molecule at low micromolar concentrations regulates a diversity of membrane proteins in an apparently

Year: 2008

Language: English

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3 Journal article

Amphiphile regulation of ion channel function by changes in the bilayer spring constant

Lundbæk, Jens August; Koeppe, R.E.; Andersen, Oluf Sten

Proceedings of the National Academy of Sciences of the United States of America — 2010, Volume 107, Issue 35, pp. 15427-15430

be predicted from measurements of isolated changes in such properties. Thus, the bilayer contribution to the promiscuous regulation of membrane proteins by drugs and other amphiphiles remains unknown. To overcome this problem, we use gramicidin A (gA) channels as molecular force probes to measure the net

Year: 2010

Language: English

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4 Journal article

Linear rate-equilibrium relations arising from ion channel-bilayer energetic coupling

Greisen, Per Junior; Lum, Kevin; Ashrafuzzaman, Md; Greathouse, Denise V; Andersen, Olaf S; Lundbæk, Jens August

Proceedings of the National Academy of Sciences — 2011, Volume 108, Issue 31, pp. 12717-12722

Linear rate-equilibrium (RE) relations, also known as linear free energy relations, are widely observed in chemical reactions, including protein folding, enzymatic catalysis, and channel gating. Despite the widespread occurrence of linear RE relations, the principles underlying the linear relation

Year: 2011

Language: English

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