Journal article
Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes
PROSYS - Process and Systems Engineering Centre, Department of Chemical and Biochemical Engineering, Technical University of Denmark1
Department of Chemical and Biochemical Engineering, Technical University of Denmark2
KT Consortium, Department of Chemical and Biochemical Engineering, Technical University of Denmark3
Technische Hochschule Nürnberg4
The biomanufacturing industry has now the opportunity to upgrade its production processes to be in harmony with the latest industrial revolution. Technology creates capabilities that enable smart manufacturing while still complying with unfolding regulations. However, many biomanufacturing companies, especially in the biopharma sector, still have a long way to go to fully benefit from smart manufacturing as they first need to transition their current operations to an information-driven future.
One of the most significant obstacles towards the implementation of smart biomanufacturing is the collection of large sets of relevant data. Therefore, in this work, we both summarize the advances that have been made to date with regards to the monitoring and control of bioprocesses, and highlight some of the key technologies that have the potential to contribute to gathering big data.
Empowering the current biomanufacturing industry to transition to Industry 4.0 operations allows for improved productivity through information-driven automation, not only by developing infrastructure, but also by introducing more advanced monitoring and control strategies.
Language: | English |
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Publisher: | Springer International Publishing |
Year: | 2020 |
Pages: | 947-964 |
Journal subtitle: | Official Journal of the Society for Industrial Microbiology and Biotechnology |
ISSN: | 14765535 and 13675435 |
Types: | Journal article |
DOI: | 10.1007/s10295-020-02308-1 |
ORCIDs: | Gargalo, Carina L , Udugama, Isuru , Nielsen, Rasmus F. , Hasanzadeh, Aliyeh , Mansouri, Seyed Soheil , Junicke, Helena and Gernaey, Krist V. |