Journal article
Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy
The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month.
The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model.
| Language: | English |
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| Publisher: | SPIE-Intl Soc Optical Eng |
| Year: | 2004 |
| Pages: | 553-557 |
| ISSN: | 15602281 and 10833668 |
| Types: | Journal article |
| DOI: | 10.1117/1.1689337 |
Aged Algorithms Calibration Dialysis Dialysis Solutions Dual-beam Equipment Failure Analysis Fourier transform spectroscopy Hemodialysis Solutions Humans Male Middle Aged Near-infrared Online Online Systems Reproducibility of Results Sensitivity and Specificity Spectroscopy Spectroscopy, Fourier Transform Infrared Urea bio-optics biochemistry blood condition monitoring dialysis dual-beam infrared spectroscopy mean square error methods near-infrared online organic compounds patient monitoring patient treatment spectroscopy urea
