Journal article
Co(salen)-mediated enantioselective radiofluorination of epoxides. Radiosynthesis of enantiomerically enriched [18F]F-MISO via kinetic resolution
In
Journal of Fluorine Chemistry
—
2013, Volume 156, pp. 130-135
Abstract
The first example of transition metal mediated enantioselective radiofluorination of epoxides is reported. The procedure utilizes gaseous [18F]HF in a combination with (−)tetramisole and (R,R)-Co(salen), giving the corresponding (S,S)-18F-fluorohydrines in 78–93% radiochemical yield (RCY) and 20–46% enantioselectivities (ee).
The use of this methodology allowed for a single step radiosynthesis of [18F]F-MISO, which took 1.5h and after solid phase-based purification delivered [18F]F-MISO in 81%/45% analytical/preparative RCY and 55% ee.
| Language: | English |
|---|---|
| Year: | 2013 |
| Pages: | 130-135 |
| ISSN: | 18733328 and 00221139 |
| Types: | Journal article |
| DOI: | 10.1016/j.jfluchem.2013.09.006 |
| ORCIDs: | Zhuravlev, Fedor |
Keywords
