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Journal article

Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils

By Sacco, Pasquale1; Decleva, Eva1; Tentor, Fabio2,3; Menegazzi, Renzo1; Borgogna, Massimiliano1; Paoletti, Sergio1; Kristiansen, Kåre Andre4; Vårum, Kjell Morten4; Marsich, Eleonora1

From

University of Trieste1

Department of Micro- and Nanotechnology, Technical University of Denmark2

Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark3

Norwegian University of Science and Technology4

Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark5

Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion.

Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained.

Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases.

Language: English
Year: 2017
ISSN: 16165195 and 16165187
Types: Journal article
DOI: 10.1002/mabi.201700214
ORCIDs: Tentor, Fabio
Keywords

Animals Butyrates Cell Adhesion Chitosan Drug Liberation Endocytosis Fibronectins Humans Hyaluronic Acid Hydrogen Peroxide Mucins Nanoparticles Neutrophil Activation Neutrophils Reactive Oxygen Species Superoxides Sus scrofa Tumor Necrosis Factor-alpha butyrate chitosan/hyaluronan nanoparticles human neutrophils inflammation reactive oxygen species

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