Journal article
Cantilever-based micro-particle filter with simultaneous single particle detection
Department of Micro- and Nanotechnology, Technical University of Denmark1
Nanoprobes Group, NanoSystemsEngineering Section, Department of Micro- and Nanotechnology, Technical University of Denmark2
NanoSystemsEngineering Section, Department of Micro- and Nanotechnology, Technical University of Denmark3
Currently, separation of whole blood samples on lab-on-a-chip systems is achieved via filters followed by analysis of the filtered matter such as counting of blood cells. Here, a micro-chip based on cantilever technology is developed, which enables simultaneous filtration and counting of micro-particles from a liquid.
A hole-array is integrated into a micro-cantilever, which is inserted into a microfluidic channel perpendicular to the flow. A metal pad at the apex of the cantilever enables an optical read-out of the deflection of the cantilever. When a micro-particle is too large to pass a hole in the cantilever, clogging of the holes increases the flow resistance of the cantilever.
This causes a bending of the device, which can be detected by the optical read-out system. By arranging an array of such cantilevers with different hole sizes, separation by size can be achieved. In this paper a proof of concept of the device is demonstrated by filtering and counting 20 mu m polystyrene beads dispersed in an aqueous solution.
Language: | English |
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Year: | 2011 |
Pages: | 054022 |
ISSN: | 13616439 and 09601317 |
Types: | Journal article |
DOI: | 10.1088/0960-1317/21/5/054022 |
ORCIDs: | Keller, Stephan Sylvest and Boisen, Anja |