Parallelized system for biopolymer degradation studies through automated microresonator measurement in liquid flow

In this work we present a novel automated system which allows the study of enzymatic degradation of biopolymer films coated on micromechanical resonators. The system combines an optical readout based on Blu-Ray technology with a software-controlled scanning mechanism. Integrated with a microfluidic setup unit, the system allows high-throughput measurements of resonance frequency over microresonator arrays under controlled flow conditions.

We here demonstrate the acquisition of statistical data on biopolymer films degradation under enzymatic reaction over a large sample of micromechanical resonators. The system has been proved to be able to perform measurements both in air and in liquid environment.