Journal article
Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide
A synthetic peptide octaarginine which mimics human immunodeficiency virus-1, Tat protein is used as cell penetrating moiety for new pH nanosensors which demonstrate enhanced cellular uptake and expanded measurement range from pH 3.9 to pH 7.3 by simultaneously incorporating two complemental pH-sensitive fluorophores in a same nanoparticle.
The authors believe that this triple fluorescent pH sensor provides a new tool to pH measurements that can have application in cellular uptake mechanism study and new nanomedicine design.
| Language: | English |
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| Publisher: | The Institution of Engineering and Technology |
| Year: | 2016 |
| Pages: | 8-12 |
| ISSN: | 1751875x and 17518741 |
| Types: | Journal article |
| DOI: | 10.1049/iet-nbt.2014.0070 |
| ORCIDs: | Andresen, Thomas Lars |
Biosensing Techniques Cell-Penetrating Peptides Fluorescent Dyes HeLa Cells Humans Hydrogen-Ion Concentration Oligopeptides biochemistry biomedical measurement biomembrane transport biomimetics biosensors cell penetrating moiety cell penetrating peptide cellular uptake mechanism study chemical sensors complemental pH‐sensitive fluorophore incorporation dyes extended measurement range human immunodeficiency virus‐1 Tat protein mimicking microorganisms molecular biophysics molecular configurations nanocomposites nanofabrication nanomedicine nanomedicine design nanoparticle nanoparticles nanosensors octaarginine optical sensors pH measurement polymeric pH nanosensor polymers proteins spectrochemical analysis synthetic peptide triple fluorescent pH sensor
