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Conference paper

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation

In Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society — 2013

By Marizza, Paolo^1,2; Keller, Stephan Sylvest^1,2; Rades, T.³; Müllertz, A.³; Kikic, I.⁴; Moneghini, M.⁴; De Zordi, N.⁴; Solinas, D.⁴; Boisen, Anja^1,2

From

Department of Micro- and Nanotechnology, Technical University of Denmark¹

Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark²

University of Copenhagen³

University of Trieste⁴

Abstract

In this work we present an effective loading technique of micro-containers for oral drug delivery of a poorly water soluble drug in a solid dispersion with polymer. By combining inkjet printing and supercritical CO2 impregnation we load ketoprofen in a solid dispersion with poly(vinylpyrrolidone) (PVP) into cylindrical micro-containers providing unidirectional release.

Both the printing and the impregnation step can be tuned in order to control drug loading with accuracy in the range of micro-grams.

Language:	English
Year:	2013
Proceedings:	40th Annual Meeting & Exposition of the Controlled Release Society
Types:	Conference paper
ORCIDs:	Keller, Stephan Sylvest and Boisen, Anja

Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation

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Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO2 aided-impregnation

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Drug-polymer filled micro-containers for oral delivery loaded using supercritical CO₂ aided-impregnation