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Conference paper

Feasibility of bovine submaxillary mucin (BSM) films as biomimetic coating for polymeric biomaterials

In Proceedings of the Iasted International Conference on Biomedical Engineering, Biomed 2013 — 2013, pp. 591-597

By Lee, Seunghwan1,2; Madsen, Jan Busk1,2,3; Pakkanen, Kirsi I.1,2

From

Department of Mechanical Engineering, Technical University of Denmark1

Materials and Surface Engineering, Department of Mechanical Engineering, Technical University of Denmark2

Enzyme and Protein Chemistry, Department of Systems Biology, Technical University of Denmark3

Feasibility of bovine submaxillary mucin (BSM) films generated via spontaneous adsorption from aqueous solutions onto polydimethylsiloxane (PDMS) and polystyrene (PS) surfaces have been investigated as biomimetic coatings for polymeric biomaterials. Two attributes as biomedical coatings, namely anti-fouling properties and lubricity, have been focused on in this study.

Optical waveguide light-mode spectroscopy (OWLS) and fluorescence microscopy studies have shown that albumin, fibrinogen, immunoglobulin G, and serum rapidly adsorb onto BSM layers formed on PDMS and PS surfaces. Pin-on-disk tribometry, employing compliant PDMS as tribopairs, has shown that BSM coatings generated on PDMS surface via spontaneous adsorption from aqueous solution has effective lubricating properties, but for very limited duration only.

Language: English
Year: 2013
Pages: 591-597
Proceedings: The 10th IASTED International Conference on Biomedical Engineering
Types: Conference paper
DOI: 10.2316/P.2013.791-166
ORCIDs: Lee, Seunghwan
Keywords

Biofouling Biomedical coating Bovine submaxillary mucin (BSM) Lubricity

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