Journal article
Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients
Unilever1
Brown University2
National Institute of Public Health and the Environment3
University of Maryland, College Park4
Japan Cosmetic Industry Association5
Clariant Produkte GmbH6
BAIF Development Research Foundation7
Procter & Gamble Technical Centres Ltd8
Cosmetics Alliance Canada9
Universidade Federal de Goiás10
Agência Nacional de Vigilância Sanitária11
Public Health Agency of Canada12
Vrije Universiteit Brussel13
Cosmetics Europe – The Personal Care Association14
Chutoen General Medical Center15
Humane Society International16
Taiwan Cosmetic Industry Association17
United States Environmental Protection Agency18
L'Oréal19
National Institute of Health Sciences Tokyo20
European Commission21
US Personal Care Products Council22
Research Group for Chemical Risk Assessment and GMO, National Food Institute, Technical University of Denmark23
National Food Institute, Technical University of Denmark24
...and 14 moreNext generation risk assessment (NGRA) is an exposure-led, hypothesis-driven approach that has the potential to support animal-free safety decision-making. However, significant effort is needed to develop and test the in vitro and in silico (computational) approaches that underpin NGRA to enable confident application in a regulatory context.
A workshop was held in Montreal in 2019 to discuss where effort needs to be focussed and to agree on the steps needed to ensure safety decisions made on cosmetic ingredients are robust and protective. Workshop participants explored whether NGRA for cosmetic ingredients can be protective of human health, and reviewed examples of NGRA for cosmetic ingredients.
From the limited examples available, it is clear that NGRA is still in its infancy, and further case studies are needed to determine whether safety decisions are sufficiently protective and not overly conservative. Seven areas were identified to help progress application of NGRA, including further investments in case studies that elaborate on scenarios frequently encountered by industry and regulators, including those where a 'high risk' conclusion would be expected.
These will provide confidence that the tools and approaches can reliably discern differing levels of risk. Furthermore, frameworks to guide performance and reporting should be developed.
Language: | English |
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Year: | 2021 |
Pages: | 105026 |
ISSN: | 10960295 and 02732300 |
Types: | Journal article |
DOI: | 10.1016/j.yrtph.2021.105026 |
ORCIDs: | Bennekou, Susanne Hougaard |