Conference paper
phuR intergenic mutation results in pleiotropic effects on global gene expression
We have previously found a positive selection for promoter mutations in Pseudomonas aeruginosa DK2 leading to increased expression of the phu (Pseudomonas heme utilization) system. By mimicking conditions of the CF airways in vitro, we experimentally demonstrated that increased expression of phuR confers a growth advantage in the presence of hemoglobin, thus suggesting that P. aeruginosa evolves towards iron acquisition from hemoglobin.
Language: | English |
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Publisher: | American Society for Microbiology |
Year: | 2015 |
Pages: | 126-127 |
Proceedings: | The ASM Conference on Pseudomonas 2015 |
Types: | Conference paper |
ORCIDs: | Khademi, Seyed Mohammad Hossein and Jelsbak, Lars |