Journal article
Differential expression of small RNAs under chemical stress and fed-batch fermentation in E. coli
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark1
Bacterial Cell Factories, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Bacterial Cell Factory Optimization, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
Bacterial small RNAs (sRNAs) are recognized as posttranscriptional regulators involved in the control of bacterial lifestyle and adaptation to stressful conditions. Although chemical stress due to the toxicity of precursor and product compounds is frequently encountered in microbial bioprocessing applications, the involvement of sRNAs in this process is not well understood.
We have used RNA sequencing to map sRNA expression in E. coli under chemical stress and high cell density fermentation conditions with the aim of identifying sRNAs involved in the transcriptional response and those with potential roles in stress tolerance.
| Language: | English |
|---|---|
| Publisher: | BioMed Central |
| Year: | 2015 |
| Pages: | 1051 |
| ISSN: | 14712164 |
| Types: | Journal article |
| DOI: | 10.1186/s12864-015-2231-8 |
| ORCIDs: | Nielsen, Alex Toftgaard |
Chemical stress CyaR Fermentation MicF OmrB RNA-seq RybB RyhB sRNA
