Journal article
Inflammatory response of different chicken lines and B haplotypes to infection with infectious bursal disease virus
Section of Poultry Diseases, Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark1
Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark2
National Veterinary Institute, Technical University of Denmark3
Chickens representing two different inbred lines (layer and meat-type) and three different B haplotypes (BW1, B19 and B131) were infected with infectious bursal disease virus (IBDV) at 21 days of age. Mortality was recorded, and surviving chickens were killed and examined either 3 or 17 days post-infection.
Non-infected control chickens were run in parallel. The variables recorded were all significantly changed by the virus infection, including the serum concentration of mannan-binding lectin that was increased 2-fold 3 days post-infection. A significantly increased mortality, liver to body weight ratio and erythrocyte sedimentation rate (ESR) was seen among chickens from the layer type line compared with the meat-type line.
In addition, the haplotype of the chickens influenced the atrophy and hypertrophy of the thymus, It was concluded that the meat-type chicken line was more resistant to IBDV infection than the layer-type line, and that mortality rate, liver to body weight ratio and ESR were valuable variables for evaluation of the level of IBDV infection-induced inflammation and disease.
Language: | English |
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Publisher: | Informa UK Limited |
Year: | 1998 |
Pages: | 181-189 |
ISSN: | 14653338 and 03079457 |
Types: | Journal article |
DOI: | 10.1080/03079459808419321 |