Journal article
Process modelling and simulation of a transketolase mediated reaction; analysis of alternative modes of operation
In
Biochemical Engineering Journal
—
2009, Volume 47, Issue 1-3, pp. 10-18
Abstract
A previously proposed model of a transketolase catalysed carbon–carbon bond formation reaction condensing β-hydroxypyruvate and glycolaldehyde to synthesise l-erythrulose has been extended to describe various modes of operation as an alternative to a batch process. The alternative continuous and fed-batch operations, with each substrate being fed separately and together have been analysed using the extended model.
The analysis was carried out simulating the product concentration after a given time under defined process conditions. Comparison of product concentration and yield on catalyst as two process metrics were used to identify promising cases for further process development.
| Language: | English |
|---|---|
| Year: | 2009 |
| Pages: | 10-18 |
| ISSN: | 1873295x and 1369703x |
| Types: | Journal article |
| DOI: | 10.1016/j.bej.2009.02.014 |
| ORCIDs: | Woodley, John |
