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Journal article

Use of a new glass microfibre histamine release method to study the modulation of the host response in human schistosomiasis mansoni. Individuals with different degrees of exposure to the disease show differing antibody biological function

By Satti, M.Z.; Ebbesen, F.; Vennervald, B.; Lind, Peter1,2,3; Ghalib, H.; Sulaiman, S.; Daffalla, A.; Skov, P.S.

From

Section for Veterinary Epidemiology and public sector consultancy, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark1

Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark2

National Veterinary Institute, Technical University of Denmark3

A new glass microfibre histamine release method was used to study the modulation of the host response in human schistosomiasis mansoni to improve our understanding of the role of basophils in the development of immunity in schistosomiasis mansoni. The histamine release from umbilical cord blood basophils sensitized with sera from Sudanese individuals infected with Schistosoma mansoni was measured.

Schistosomiasis sera (n=113) were able to passively sensitize basophils and induce a positive histamine release in response to whole worm homogenate (WWH)(chi(2)=40.5, P

Language: English
Year: 1996
Pages: 655-666
ISSN: 13653156 and 13602276
Types: Journal article
DOI: 10.1111/j.1365-3156.1996.tb00091.x
Keywords

SDG 3 - Good Health and Well-being basophils cord blood histamine resistance schistosomiasis

Other keywords

Adult Antibodies, Helminth Basophils Female Fetal Blood Glass Histamine Release Humans Immunoglobulin E Immunoglobulin G Schistosomiasis mansoni

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