Journal article
Specifically targeted gene therapy for small-cell lung cancer
Department of Radiation Biology, The Finsen Center, section 6321, Copenhagen University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.1
Small-cell lung cancer (SCLC) is a highly malignant disease with poor prognosis. Hence, there is great demand for new therapies that can replace or supplement the current available treatment regimes. Gene therapy constitutes a promising strategy and relies on the principle of introducing exogenous DNA into malignant cells causing them to die.
Since SCLC is a highly disseminated malignancy, the gene therapeutic agent must be administered systemically, obligating a high level of targeting of tumor tissue and the use of delivery vehicles designed for systemic circulation of the therapeutic DNA. This review describes and discusses the current status of the application of gene therapy in relation to SCLC.
| Language: | English |
|---|---|
| Year: | 2009 |
| Pages: | 437-452 |
| ISSN: | 17448328 and 14737140 |
| Types: | Journal article |
| DOI: | 10.1586/era.09.10 |
Adenoviridae Animals Antineoplastic Combined Chemotherapy Protocols Carcinoma, Small Cell Cell Line, Tumor Combined Modality Therapy DNA, Recombinant Drug Delivery Systems Drug Design Genes, Synthetic Genes, Transgenic, Suicide Genes, Tumor Suppressor Genetic Therapy Genetic Vectors Humans Liposomes Lung Neoplasms Mice Promoter Regions, Genetic Transcription, Genetic Xenograft Model Antitumor Assays
