Journal article
Thymidine kinase diversity in bacteria
Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.
| Language: | English |
|---|---|
| Year: | 2006 |
| Pages: | 1153-1158 |
| ISSN: | 15322335 and 15257770 |
| Types: | Journal article |
| DOI: | 10.1080/15257770600894469 |
deoxyribonucleoside kinase evolution nucleic acids precursors nucleosides pyrimidines thymidine kinase
Amino Acid Sequence Bacteria Evolution, Molecular Gene Expression Regulation, Bacterial Humans Models, Molecular Molecular Sequence Data Nucleosides Open Reading Frames Phosphotransferases (Alcohol Group Acceptor) Phylogeny Pyrimidines Sequence Homology, Amino Acid Species Specificity Thymidine Kinase deoxyribonucleoside kinases
