Journal article
Expedient total synthesis of pyrrothine natural products and analogs
This paper describes an expedient and straightforward total synthesis of the two pyrrothine natural products holomycin (7 steps, 11% overall) and xenorhabdin I (7 steps, 11% overall) and analogs thereof via a common late-stage intermediate. The pathway proceeds via the pyrrothine hydrochloride intermediate (6 steps, 17% overall) which also gave access to very fast synthesis of analogs as demonstrated by the synthesis of, and (7 steps, 11-12% overall).
Language: | English |
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Publisher: | The Royal Society of Chemistry |
Year: | 2007 |
Pages: | 344-348 |
ISSN: | 14770539 and 14770520 |
Types: | Journal article |
DOI: | 10.1039/b616411k |
ORCIDs: | 0000-0002-2854-8188 |