Journal article
The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
Utrecht University1
National Veterinary Institute, Technical University of Denmark2
Section for Immunology and Vaccinology, National Veterinary Institute, Technical University of Denmark3
Innate Immunology, Division of Immunology & Vaccinology, National Veterinary Institute, Technical University of Denmark4
Innate defense mechanisms are aimed at quickly containing and removing infectious microorganisms and involve local stromal and immune cell activation, neutrophil recruitment and activation and the induction of host defense peptides (defensins and cathelicidins), acute phase proteins and complement activation.
As an alternative to antibiotics, innate immune mechanisms are highly relevant as they offer rapid general ways to, at least partially, protect against infections and enable the build-up of a sufficient adaptive immune response. This review describes two classes of promising alternatives to antibiotics based on components of the innate host defense.
First we describe immunoglobulins applied to mimic the way in which they work in the newborn as locally acting broadly active defense molecules enforcing innate immunity barriers. Secondly, the potential of host defense peptides with different modes of action, used directly, induced in situ or used as vaccine adjuvants is described.
Language: | English |
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Publisher: | BioMed Central |
Year: | 2018 |
Pages: | 68 |
ISSN: | 12979716 and 09284249 |
Types: | Journal article |
DOI: | 10.1186/s13567-018-0558-2 |
ORCIDs: | Hedegaard, Chris Juul , Heegaard, Peter Mikael Helweg and 0000-0002-4931-5201 |