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Journal article

Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage

By Lorenzen, Niels1,2,3; Lorenzen, Ellen1,2,3; Einer-Jensen, Katja1,2,3

From

Section of Fish Diseases, Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark1

Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark2

National Veterinary Institute, Technical University of Denmark3

Rainbow trout fry of average weight 0.5 g were vaccinated against viral haemorrhagic septicaemia (VHS) by intramuscular injection of 1 mug of plasmid DNA encoding the VHS virus glycoprotein gene. Challenge with a lethal dose of virus at two different time points, 9 and 71 days post-vaccination respectively, revealed that a highly protective and lasting immunity was established shortly after vaccination, in accordance with earlier experiments with larger fish.

The defence mechanisms activated by the DNA vaccine are thus functional at an early life-stage in rainbow trout.

Language: English
Year: 2001
Pages: 585-591
ISSN: 10959947 and 10504648
Types: Journal article
DOI: 10.1006/fsim.2001.0337
ORCIDs: Lorenzen, Niels
Keywords

SDG 3 - Good Health and Well-being early immunity genetic immunisation plasmid DNA rainbow trout fry rhabdovirus

Other keywords

Animals Fish Diseases Glycoproteins Injections, Intramuscular Novirhabdovirus Oncorhynchus mykiss Rhabdoviridae Infections Survival Analysis Vaccines, DNA Viral Vaccines rhabdovirus, genetic immunisation, rainbow trout fry, plasmid DNA, early immunity

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