Journal article
New azaphilones from Aspergillus neoglaber
Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark1
Natural Product Discovery, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark2
Department of Biotechnology and Biomedicine, Technical University of Denmark3
Section for Synthetic Biology, Department of Biotechnology and Biomedicine, Technical University of Denmark4
Fungal Chemodiversity, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark5
Center for Microbial Secondary Metabolites, Centers, Technical University of Denmark6
Technical University of Denmark7
Three new azaphilones, sassafrin E ( 1 ), sassafrin F ( 2 ), and sassafrinamine A ( 3 ), were isolated from the filamentous fungus Aspergillus neoglaber. The structures of the compounds were determined by nuclear magnetic resonance spectroscopy, and were found to be novel analogues of two already known compound classes; sassafrins and berkchaetoazaphilones.
Sassafrin E and F were both oxygen containing, while sassafrinamine A additionally contained a nitrogen atom, originating from an aminoethanol moiety, as well as extensive conjugation resulting in an intense purple colour of the pure compound. The structure of sassafrin E was further confirmed using deuterium exchange experiments coupled with high-resolution tandem mass spectrometry.
| Language: | English |
|---|---|
| Publisher: | Springer Berlin Heidelberg |
| Year: | 2020 |
| Pages: | 145 |
| ISSN: | 21910855 |
| Types: | Journal article |
| DOI: | 10.1186/s13568-020-01078-4 |
| ORCIDs: | Isbrandt, Thomas , Frisvad, Jens Christian and Larsen, Thomas Ostenfeld |
