Report
Design of a process template for amine synthesis
Department of Chemical and Biochemical Engineering, Technical University of Denmark1
Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark2
AstraZeneca3
Karlsruhe Institute of Technology4
CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark5
A conceptual nitro reduction process template that should be generic such that it can handle a series of substrates with sim ilar molecular functionality has been designed. The reduction process is based on a continuo us plug-flow slurry reactor. The process template aims at speeding up the process development for new substrates by being easily adapted for a range of substrates as well as easily scaled by numbering-up.
The potential saving in process development time could make it a particularly powerful experimental tool for early delivery campaigns in the pharmaceutical industry for the production of Kg amounts of material for clinical trials.
| Language: | English |
|---|---|
| Publisher: | Technical University of Denmark, Department of Chemical and Biochemical Engineering |
| Year: | 2015 |
| Series: | Capec-process Report |
| Types: | Report |
| ORCIDs: | Gernaey, Krist and Woodley, John |
