Journal article
Pyrrolidinone-modified di- and tripeptides: highly diastereoselective preparation and investigation of their stability
Pyrrolidine-2,4-diones have been identified as a novel starting point for the synthesis of peptide analogues. This paper describes a method for the efficient and diastereoselective incorporation of this moiety into peptide chains to furnish di- and tripeptide analogs. The stability of these pyrrolidinone modified di- and tripeptides was found to be markedly improved when compared to that of a natural peptide.
In addition, solid phase peptide synthesis employing a pyrrolidinone containing tripeptide is demonstrated.
Language: | English |
---|---|
Year: | 2007 |
Pages: | 3486-3494 |
ISSN: | 15222667 , 09317597 , 14770539 and 14770520 |
Types: | Journal article |
DOI: | 10.1002/chin.200812204 |
ORCIDs: | Tanner, David Ackland |