Journal article
epi-Aszonalenins A, B, and C from Aspergillus novofumigatus
Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark1
Department of Systems Biology, Technical University of Denmark2
X-ray Crystallography, Department of Chemistry, Technical University of Denmark3
Department of Chemistry, Technical University of Denmark4
Organic Chemistry, Department of Chemistry, Technical University of Denmark5
Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data.
The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
Language: | English |
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Year: | 2006 |
Pages: | 6099-6102 |
ISSN: | 18733581 and 00404039 |
Types: | Journal article |
DOI: | 10.1016/j.tetlet.2006.06.086 |
ORCIDs: | Harris, Pernille , Frisvad, Jens Christian , Gotfredsen, Charlotte Held and Larsen, Thomas Ostenfeld |