Journal article
Taichunins E-T, Isopimarane Diterpenes and a 20-nor-Isopimarane, from Aspergillus taichungensis (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts
Kumamoto University1
Center for Microbial Secondary Metabolites, Centers, Technical University of Denmark2
Fungal Chemodiversity, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark3
Department of Biotechnology and Biomedicine, Technical University of Denmark4
Colorado State University5
Fifteen new isopimarane-type diterpenes, taichunins E-S ( 1-15 ), and a new 20-nor-isopimarane, taichunin T ( 16 ), together with four known compounds were isolated from Aspergillus taichungensis (IBT 19404). The structures of these new compounds were determined by NMR and mass spectroscopy, and their absolute configurations were analyzed by NOESY and TDDFT calculations of ECD spectra.
Taichunins G, K, and N ( 3 , 7 , and 10 ) completely inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts in RAW264 cells at 5 μM, with 3 showing 92% inhibition at a concentration of 0.2 μM.
| Language: | English |
|---|---|
| Publisher: | American Chemical Society and American Society of Pharmacognosy |
| Year: | 2021 |
| Pages: | 2475-2485 |
| ISSN: | 15206025 and 01633864 |
| Types: | Journal article |
| DOI: | 10.1021/acs.jnatprod.1c00486 |
| ORCIDs: | 0000-0001-9063-1284 , 0000-0002-7993-381X and Frisvad, Jens C. |
