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Conference paper

Validation of a Simulation Model Describing the Glucose-Insulin-Glucagon Pharmacodynamics in Patients with Type 1 Diabetes

By Wendt, Sabrina Lyngbye1,2; Ranjan, Ajenthen3; Møller, Jan Kloppenborg1,4; Schmidt, Signe3; Boye Knudsen, Carsten5; Holst, Jens Juul6; Madsbad, Sten3; Madsen, Henrik1,4; Nørgaard, Kirsten3; Jørgensen, John Bagterp1,2,7,8

From

Department of Applied Mathematics and Computer Science, Technical University of Denmark1

Scientific Computing, Department of Applied Mathematics and Computer Science, Technical University of Denmark2

Copenhagen University Hospital Herlev and Gentofte3

Dynamical Systems, Department of Applied Mathematics and Computer Science, Technical University of Denmark4

Zealand Pharma A/S5

University of Copenhagen6

Copenhagen Center for Health Technology, Centers, Technical University of Denmark7

Center for Energy Resources Engineering, Centers, Technical University of Denmark8

Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determine the glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need a validated glucoregulatory model including the effect of glucagon.

Language: English
Year: 2017
Proceedings: Advanced Technology and Treatments for Diabetes 2017
Types: Conference paper
ORCIDs: Wendt, Sabrina Lyngbye , Møller, Jan Kloppenborg , Madsen, Henrik and Jørgensen, John Bagterp
Keywords

SDG 3 - Good Health and Well-being

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