Journal article
Solid-Phase Synthesis of PEGylated Lipopeptides Using Click Chemistry
Colloids and Biological Interfaces Group, Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark1
Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark2
Department of Micro- and Nanotechnology, Technical University of Denmark3
A versatile methodology for efficient synthesis of PEGylated lipopeptides via CuAAC “Click” conjugation between alkyne-bearing solid-supported lipopeptides and azido-functionalized PEGs is described. This new and very robust method offers a unique platform for synthesizing PEGylated lipopeptides with a high level of complexity.
These molecules, obtained in a single purification step, are ideally suited for functionalization of solid-supported lipid bilayers and liposomal drug delivery systems and are particularly valuable in enzyme activation strategies.
Language: | English |
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Year: | 2010 |
Pages: | 807-810 |
ISSN: | 15204812 and 10431802 |
Types: | Journal article |
DOI: | 10.1021/bc100002a |
ORCIDs: | Andresen, Thomas Lars |