Journal article
Determination of octanol-water partition coefficients of polar polycyclic aromatic compounds (N-PAC) by high performance liquid chromatography
Prediction of 1-octanol water partition coefficients for a range of polar N-PAC from HPLC capacity coefficients has been investigated. Two commercially available columns, an ODS column and a Diol column were tested with water-methanol eluents. The best prediction of log K-ow for N-PAC was achieved using a Diol column with an eluent of 35 % MeOH and 65 % water.
The results indicate that the Diol column, in reversed phase mode, is able to form hydrogen bonds with a solute. Different LFERs between retention and log K-ow was found for polar and nonpolar compounds. In general log K-ow increased with size and log K-ow for N-PAC was 1.1-1.3 lower than log K-ow for the equivalent PAH.
Shielding of the nitrogen atom in the N-PAC compounds caused an increase in log K-ow. (C) 1997 Elsevier Science Ltd.
Language: | English |
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Year: | 1997 |
Pages: | 1673-1684 |
ISSN: | 18791298 and 00456535 |
Types: | Journal article |
DOI: | 10.1016/S0045-6535(97)00024-6 |