Journal article
Decarboxylation-based traceless linking with aroyl acrylic acids
beta-Keto carboxylic acids are known to decarboxylate readily. In our pursuit to synthesize beta-indolinyl propiophenones, we have exploited this chemistry as a mean of establishing a traceless handle. 2-Aroyl acrylic acids have been esterified to a trityl resin, after which Michael-type addition of indolines have been performed.
Upon cleavage, the products are decarboxylated, and the beta-indolinyl propiophenones are isolated. The reaction conditions have been optimized, and a small library has been prepared. (C) 1998 Elsevier Science Ltd. All rights reserved.
Language: | English |
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Year: | 1998 |
Pages: | 2207-2210 |
ISSN: | 18733581 and 00404039 |
Types: | Journal article |
DOI: | 10.1016/S0040-4039(98)00176-2 |
ORCIDs: | 0000-0002-2854-8188 |