Journal article
Phenazines and natural products; Novel synthesis of saphenic acid
The natural product saphenic acid (6-(1-hydroxyethyl)1-phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions.
Assignments of H-1 NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.
Language: | English |
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Year: | 1999 |
Pages: | 1763-1766 |
ISSN: | 1437210x and 00397881 |
Types: | Journal article |
DOI: | 10.1055/s-1999-3587 |
ORCIDs: | 0000-0003-3525-5452 and 0000-0002-2854-8188 |