Journal article
Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein
Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants.
This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.
Language: | English |
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Year: | 1995 |
Pages: | 1033-1037 |
ISSN: | 18732518 , 13552732 and 0264410x |
Types: | Journal article |
DOI: | 10.1016/0264-410X(95)00021-R |
Amino Acid Sequence Animals Antibodies, Viral Capsid Capsid Proteins Feline Panleukopenia Virus Mink Molecular Sequence Data Neutralization Tests Parvoviridae Infections Parvovirus Parvovirus, Canine Peptides Recombinant Proteins Vaccines, Synthetic Viral Vaccines capsid protein VP2, parvovirus B19 peptide vaccine subunit vaccine