Journal article
Passive immunization of pigs against experimental infection with Streptococcus suis serotype 2
Section for Veterinary Diagnostics, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark1
Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark2
National Veterinary Institute, Technical University of Denmark3
Technical University of Denmark4
The safety and protective efficacy of a horse antiserum raised against inactivated whole cell preparations of Streptococcus suis serotype 2 was investigated in pigs by experimental challenge. The antiserum was evaluated in two similar experiments each comprising 12 4-week-old pigs treated with 6 ml of antiserum the day before challenge and four pigs used as challenge controls.
Pigs were infected by subcutaneous injection with approximately 10(11) colony forming units of S. suis serotype 2. Clinical disease in the pigs that could be attributed to infection with S. suis was reduced from 88 to 35% (P = 0.015). The percentage of pigs with lesions that could be associated with S. suis was reduced from 88 to 22% (P = 0.002) and isolation of S. suis serotype 2 was reduced from five (63%) out of eight pigs in the combined challenge control groups to 3 (13%) out of 23 pigs in the combined treatment groups.
These results indicate that passive immunization of pigs may be a way to reduce or control S. suis serotype 2 infections in pigs.
| Language: | English |
|---|---|
| Year: | 2001 |
| Pages: | 331-344 |
| ISSN: | 18732542 and 03781135 |
| Types: | Journal article |
| DOI: | 10.1016/S0378-1135(01)00359-5 |
| ORCIDs: | Andresen, Lars Ole |
