Journal article
Residential Exposure to Plasticizers and Its Possible Role in the Pathogenesis of Asthma
The plasticizer di(2-ethylhexyl)phtlalate (DEHP) is widely used in building materials. DEHP is identified as the major plasticizer exposure in dwellings. We provide evidence that inhalation exposure to DEHP as aerosols adsorbed to particulate matter is as important, or more important, than vapor phase exposure.
The particulate inhalaton exposure to DEHP is considered to be significant due to its low clearance and extensive penetration into the pulmonary region. DEHP is capable of creating high local concentrations in the airways at the deposition site with subsequent local effects. The proposed mechanism of effect states that mono(2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD2, 9alfa,11betaPGF2, and PGF2alfa, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.
Language: | English |
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Publisher: | National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare |
Year: | 1997 |
Pages: | 972-978 |
ISSN: | 15424367 , 00916765 and 15529924 |
Types: | Journal article |
DOI: | 10.1289/ehp.97105972 |
ORCIDs: | 0000-0002-2391-5284 |
Aerosols Air Pollution, Indoor Asthma Child Child, Preschool Di(2-ethylhexyl) phthalate Diethylhexyl Phthalate Environmental Exposure Female Housing Humans Inflammation Inhalation Exposure Male Mono(2-ethylhexyl) phthalate PVC Plasticizer Polyvinyl chloride Prostaglandin Thromboxane A<sub>2</sub> receptor