Journal article
Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study : Flavonoids, antioxidant capacity and hepatocellular cancer
Catalan Institute of Oncology1
Danish Cancer Society2
Centre for Research in Epidemiology and Population Health3
German Cancer Research Center4
German Institute of Human Nutrition Potsdam-Rehbruecke5
Hellenic Health Foundation6
Cancer Research and Prevention Institute7
National Cancer Institute Italy8
University of Naples Federico II9
'Civic MP Arezzo' Hospital10
Human Genetic Foundation11
International Agency for Research on Cancer12
National Institute of Public Health and the Environment13
University Medical Centre Utrecht14
University of Tromsø – The Arctic University of Norway15
Ministry of Health, Consumption and Social Welfare16
Andalusian School of Public Health17
CIBER Epidemiología y Salud Pública18
Lund University19
Umeå University20
University of Cambridge21
MRC Epidemiology Unit22
National and Kapodistrian University of Athens23
University of Oxford24
Imperial College London25
Centre de Biologie Republique26
University of Bonn27
National Research Institute for Food and Nutrition28
National Food Institute, Technical University of Denmark29
Division of Toxicology and Risk Assessment, National Food Institute, Technical University of Denmark30
Aarhus University31
...and 21 moreLimited epidemiological evidence suggests a protective role for plant foods rich in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim was to prospectively investigate the association between dietary intake of flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk.
Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 477,206 subjects (29.8% male) recruited from ten Western European countries, was analyzed. Flavonoid, lignan and NEAC intakes were calculated using a compilation of existing food composition databases linked to dietary information from validated dietary questionnaires.
Dietary NEAC was based on ferric reducing antioxidant capacity (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases (66.5% men) were identified. Using Cox regression, multivariable adjusted models showed a borderline nonsignificant association of HCC with total flavonoid intake (highest versus lowest tertile, HR = 0.65, 95% CI: 0.40-1.04; ptrend = 0.065), but not with lignans.
Among flavonoid subclasses, flavanols were inversely associated with HCC risk (HR = 0.62, 95% CI: 0.39-0.99; ptrend = 0.06). Dietary NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; ptrend = 0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; ptrend = 0.002), but statistical significance was lost after exclusion of the first 2 years of follow-up.
This study suggests that higher intake of dietary flavanols and antioxidants may be associated with a reduced HCC risk. © 2013 UICC.
| Language: | English |
|---|---|
| Year: | 2013 |
| Pages: | 2429-2443 |
| ISSN: | 10970215 , 00207136 and 08986924 |
| Types: | Journal article |
| DOI: | 10.1002/ijc.28257 |
| ORCIDs: | Bredsdorff, Lea and 0000-0001-6429-7921 |
Antioxidant capacity Dietary intake EPIC Flavonoids Hepatocellular carcinoma Lignans SDG 3 - Good Health and Well-being
Antioxidants Carcinoma, Hepatocellular Case-Control Studies Cohort Studies Diet Europe Feeding Behavior Female Follow-Up Studies Humans Liver Neoplasms Male Middle Aged Nutritional Status Prospective Studies Risk Risk Assessment Risk Factors Surveys and Questionnaires antioxidant capacity dietary intake flavonoids hepatocellular carcinoma lignans
