Journal article
Immunity induced shortly after DNA vaccination of rainbow trout against rhabdoviruses protects against heterologous virus but not against bacterial pathogens
Section of Fish Diseases, Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark1
Division of Poultry, Fish and Fur Animals, National Veterinary Institute, Technical University of Denmark2
National Veterinary Institute, Technical University of Denmark3
Clear Springs Foods Incorporated4
It was recently reported that DNA vaccination of rainbow trout fingerlings against viral hemorrhagic septicaemia virus (VHSV) induced protection within 8 days after intramuscular injection of plasmid DNA. In order to analyse the specificity of this early immunity, fish were vaccinated with plasmid DNA encoding the VHSV or the infectious haematopoietic necrosis virus (IHNV) glycoprotein genes and later challenged with homologous or heterologous pathogens.
Challenge experiments revealed that immunity established shortly after vaccination was cross-protective between the two viral pathogens whereas no increased survival was found upon challenge with bacterial pathogens. Within two months after vaccination, the cross-protection disappeared while the specific immunity to homologous virus remained high.
The early immunity induced by the DNA vaccines thus appeared to involve short-lived non-specific anti-viral defence mechanisms.
Language: | English |
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Year: | 2002 |
Pages: | 173-179 |
ISSN: | 18790089 and 0145305x |
Types: | Journal article |
DOI: | 10.1016/S0145-305X(01)00059-3 |
ORCIDs: | Lorenzen, Niels |
SDG 3 - Good Health and Well-being genetic immunization glycoprotein non-specific protection plasmid DNA rainbow trout rhabdovirus
Aeromonas Amino Acid Sequence Animals Fish Diseases Gram-Negative Bacterial Infections Infectious hematopoietic necrosis virus Logistic Models Molecular Sequence Data Novirhabdovirus Oncorhynchus mykiss Rhabdoviridae Infections Sequence Alignment Sequence Homology, Amino Acid Vaccination Vaccines, DNA Viral Vaccines Yersinia Yersinia Infections