Journal article
Statistical modelling of the interplay between solute shape and rejection in porous membranes
Department of Mathematics, Technical University of Denmark1
Applied functional analysis, Department of Mathematics, Technical University of Denmark2
Department of Chemical and Biochemical Engineering, Technical University of Denmark3
Center for BioProcess Engineering, Department of Chemical and Biochemical Engineering, Technical University of Denmark4
Dynamical systems, Department of Mathematics, Technical University of Denmark5
Computer Aided Process Engineering Center, Department of Chemical and Biochemical Engineering, Technical University of Denmark6
Membrane Technology group, Department of Chemical and Biochemical Engineering, Technical University of Denmark7
The structural conformation of complex molecules, e.g., polymers and proteins, is determined by several factors like composition of the basic structural units, charge, and properties of the surrounding solvent. In absence of any chemical or physical interaction solute–solute and/or solute–membrane, it can be expected that the possibility for a solute particle to enter the membrane pore will only depend upon the relation between such molecular conformation and pore size.
The objective of the present study is to use geometric and statistical modelling to determine the effect of particle elongation – from spherical to being increasingly prolate ellipsoidal – on the possibility of entering the pore, and, in turn, on the macroscopic distribution coefficient, K, and overall retention during filtration.
The model showed that the value of K was maximal when the longer of the radii in the prolate ellipsoid was approximately equal to the radius of the pores, in case the spherical size of the particle was smaller than the membrane pore. Furthermore, for spherical particles larger than the pore, such a maximum was found to occur after the smaller of the radii was smaller than the pore radius.
Either for spherical particles bigger or smaller than the pore radius, K was monotonically decreasing towards zero as the particles became more elongated. When relating the values of K to the friction model, the maximal rejection coefficient was found to reach a characteristic minimum when changing shape.
The results suggested that the retention during porous membrane filtration can be manipulated when working with solute particles prone to alter conformation via, e.g., adding proper functional groups to the molecule, or modifying charge density/distribution by varying pH.
Language: | English |
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Year: | 2012 |
Pages: | 261-269 |
ISSN: | 18733794 and 13835866 |
Types: | Journal article |
DOI: | 10.1016/j.seppur.2012.01.032 |
ORCIDs: | Pinelo, Manuel , Brøns, Morten and Meyer, Anne S. |