Journal article
Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography - a pilot study
Bedside diagnosis of skin cancer remains a challenging task. The real-time non-invasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging.
We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis.
Comprehensive studies involving more patients are imperative in order to corroborate results. This article is protected by copyright.
Language: | English |
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Year: | 2021 |
Pages: | e202100083 |
ISSN: | 18640648 and 1864063x |
Types: | Journal article |
DOI: | 10.1002/jbio.202100083 |
ORCIDs: | Møller Israelsen, Niels , Jensen, Mikkel and Bang, Ole |